کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8361757 1542519 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
FOXO1: Another avenue for treating digestive malignancy?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
FOXO1: Another avenue for treating digestive malignancy?
چکیده انگلیسی
Digestive malignancies are the leading cause of mortality among all neoplasms, contributing to estimated 3 million deaths in 2012 worldwide. The mortality rate hassurpassed lung cancer and prostate cancer in recent years. The transcription factor Forkhead Box O1 (FOXO1) is a key member of Forkhead Box family, regulating diverse cellular functions during tumor initiation, progression and metastasis. In this review, we focus on recent studies investigating the antineoplastic role of FOXO1 in digestive malignancy. This review aims to serve as a guide for further research and implicate FOXO1 as a potent therapeutic target in digestive malignancy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cancer Biology - Volume 50, June 2018, Pages 124-131
نویسندگان
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