کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8385041 | 1543668 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Whole-genome comparison of urinary pathogenic Escherichia coli and faecal isolates of UTI patients and healthy controls
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کلمات کلیدی
SNPsNGSWGSAdaption - اقتباسNext generation sequencing - توالی نسل بعدیmutations - جهش یا میوتیشنurinary tract infection - عفونت مجاری ادراریEvolution - فرگشت Faecal flora - فلور فقیهPhylogeny - فیلوژنیFimbria - فیمبریاEnvironment - محیط زیستMicrobiota - میکروبیوتاVirulence - ویروسی شدنPolymorphism - پلی مورفیسمGenomes - ژنوم هاGut - گل سرخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In summary, the results showed that (i) healthy women who had never previously had UTI carried faecal E. coli which were overall closely related to UTI and faecal isolates from UTI patients; (ii) UTI isolates do not cluster separately from faecal-only isolates based on SNP analysis; and (iii) 22 gene families of a genomic island, putative T6SS proteins as well as specific metabolism and virulence associated proteins were significantly more common in UTI isolates compared to faecal-only isolates and (iv) evolution of fimH for these isolates was not linked to the clinical source of the isolates, apart from the mutation combination N70S/S78N, which was correlated to UTI isolates of phylogroup B2. Combined, these findings illustrate that faecal and UTI isolates, as well as faecal-only and faecal-UTI isolates, are closely related and can only be distinguished, if at all, by their accessory genome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Medical Microbiology - Volume 307, Issue 8, December 2017, Pages 497-507
Journal: International Journal of Medical Microbiology - Volume 307, Issue 8, December 2017, Pages 497-507
نویسندگان
Karen Leth Nielsen, Marc Stegger, Kristoffer Kiil, Paul A. Godfrey, Michael Feldgarden, Berit Lilje, Paal S. Andersen, Niels Frimodt-Møller,