کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8414102 | 1545344 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bicellar systems as vehicle for the treatment of impaired skin
ترجمه فارسی عنوان
سیستم های دوچرخه به عنوان وسیله ای برای درمان کمبود پوست
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
WAXSreceptor fluidSAXSLamellar crystallineIn vitro percutaneous absorptionPβ′Lβ′LαDSCTEWLdHPCPBSDPPCBSA - BSAbovine serum albumin - آلبومین سرم گاوTransepidermal water loss - از دست دادن آب دریچهEpidermis - اِپیدرمDermis - درمیdipalmitoyl phosphatidylcholine - دیپالمیتویل فسفاتیدیل کولینDiclofenac diethylamine - دیکلوفناک دیتیلامینSurface excess - سطحی بیش از حدRipple phase - فاز لبهliquid crystalline phase - فاز کریستال مایعphosphate buffer saline - فسفات بافر شورStratum corneum - لایه شاخی، استراتوم کورنئومSmall-angle X-ray scattering - پراکندگی اشعه ایکس با زاویه کوچکWide-angle X-ray scattering - پراکندگی اشعه ایکس پاناسونیکDifferential scanning calorimetry - کالریمتری روبشی افتراقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوتکنولوژی یا زیستفناوری
چکیده انگلیسی
This study assesses the potential usefulness of bicellar systems to retard the penetration of drugs into damaged skin. The active compound used in this study was diclofenac diethylamine (DDEA). Initially, physicochemical characterisation of the DDEA bicellar systems was performed at different temperatures by small-angle X-ray scattering (SAXS), wide-angle X-ray scattering (WAXS) and differential scanning calorimetry (DSC) techniques. Subsequently, in vitro percutaneous absorption of bicellar systems into in vitro damaged skin was studied.SAXS results indicated a slight decrease in the width of their bilayers with increasing temperature, with no apparent stacking in those systems. WAXS patterns were compatible with an orthorhombic lateral packing of the nanoaggregates. The thermogram obtained by DSC indicated a decrease in gel-to-liquid crystalline transition temperature (Tm) when the drug was included into bicellar systems. A retardation effect for DDEA was detected by in vitro percutaneous absorption studies when DDEA was vehiculised in the bicellar systems with respect to an aqueous solution of the drug. It seems that the use of bicellar systems as a vehicle for topical application of DDEA on skin with an impaired barrier function may inhibit the penetration of DDEA to the systemic level. Such systems may consequently repair stratum corneum barrier function to some extent. The use of these systems could be considered a new alternative strategy to treat topically pathological skin with different drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 2, February 2014, Pages 212-218
Journal: European Journal of Pharmaceutics and Biopharmaceutics - Volume 86, Issue 2, February 2014, Pages 212-218
نویسندگان
L. Rubio, C. Alonso, G. RodrÃguez, M. Cócera, L. Barbosa-Barros, L. Coderch, A. de la Maza, J.L. Parra, O. López,