کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8419107 1545734 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of a panel of highly sensitive, equivalent assays for detection of antibody responses to velaglucerase alfa or imiglucerase enzyme replacement therapy in patients with Gaucher disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Development of a panel of highly sensitive, equivalent assays for detection of antibody responses to velaglucerase alfa or imiglucerase enzyme replacement therapy in patients with Gaucher disease
چکیده انگلیسی
► Velaglucerase alfa and imiglucerase are therapies for type 1 Gaucher disease. ► We developed assays to compare antibody response to these two replacement enzymes. ► Screening, confirmatory, isotyping, and neutralizing activity assays were developed. ► State-of-the-art methods and the latest guidance were used to validate the assays. ► The assays facilitate direct comparison of antibody responses to the two enzymes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Immunological Methods - Volume 373, Issues 1–2, 28 October 2011, Pages 45-53
نویسندگان
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