کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8434489 | 1546645 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis
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کلمات کلیدی
ras homolog family member ALIMKKelch-like ECH-associated proteinTNBCMMPNRF-2CFLRhoADMEMFBSFAKBSA - BSAkeap1 - buy1DMSO - DMSODulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoMTT - MTTOridonin - Oridonibovine serum albumin - آلبومین سرم گاوEMT - تکنسین فوریتهای پزشکیDimethyl sulfoxide - دیمتیل سولفواکسیدRho - روBreast cancer - سرطان پستانTriple-negative breast cancer - سرطان پستان سه گانه منفیfetal bovine serum - سرم جنین گاوmatrix metalloproteinase - ماتریکس متالوپروتئینازMetastasis - متاستاز Rho-associated protein kinase - پروتئین کیناز وابسته به RhoCofilin - کوفیلینfocal adhesion kinase - کیناز چسبندگی کانونیEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیEstrogen receptor - گیرنده استروژنRock - یا راک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Metastasis is a major cause of breast cancer-associated mortality. Natural products extracted from herbs provide rich bioactive compounds with anticancer efficacy but may have limited or moderate potency and considerable toxicity. We developed a novel aziridonin, YD0514, by aziridinating oridonin, a natural product of the medicinal herb Rabdosia rubescens. In this study, we found that YD0514 significantly inhibited proliferation, motility, and adhesion of metastatic breast cancer cell lines MDA-MB-231, GI101, GILM2, and GILM3. YD0514 also decreased the protein expression of matrix metalloproteinases 2 and 9 (MMP2 and MMP9), focal adhesion kinase (FAK), and integrin family members. Importantly, YD0514 suppressed the growth of metastatic breast cancer xenograft tumors and significantly inhibited lung metastasis in vivo. Lastly, we showed that YD0514's anti-metastatic effect on highly aggressive breast cancer is mediated via regulating the NRF-2/RHOA/ROCK signaling pathway. These results demonstrate that YD0514, the first active analog based on an oridonin D-ring modification, has the potential to be developed as an anti-metastasis therapy for patients with metastatic cancers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 424, 28 June 2018, Pages 97-108
Journal: Cancer Letters - Volume 424, 28 June 2018, Pages 97-108
نویسندگان
Dengfeng Li, Hong Wang, Ye Ding, Ziwei Zhang, Zhi Zheng, Jiabin Dong, Hyejin Kim, Xiaojing Meng, Qianjun Zhou, Jia Zhou, Lin Fang, Qiang Shen,