کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8463503 | 1549321 | 2012 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vesicular Ca2+ mediates granule motion and exocytosis
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
sarcoplasmic reticulum calcium ATPaseSGIICGACGSV-ATPaseTIRFMVMAT2LDCVChromograninsCgBAmperometry - آمپرومتری Ca2+-induced Ca2+ release - انتشار Ca2 + ناشی از Ca2 +Exocytosis - اگزوسیتوزBafilomycin - بافیلومایسینSecretion - ترشح Vesicular monoamine transporter - حامل مونوآمین VesicularLarge dense core vesicles - حنجره های بزرگ متراکم مرکزیSERCA - قلبChromogranin A - کروموگرانین Achromogranin B - کروموگرانین BCalcium - کلسیمCICR - کمیته بینالمللی صلیب سرخ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Secretory vesicles of chromaffin cells are acidic organelles that maintain an increasing pH gradient towards the cytosol (5.5 vs. 7.3) that is mediated by V-ATPase activity. This gradient is primarily responsible for the accumulation of large concentrations of amines and Ca2+, although the mechanisms mediating Ca2+ uptake and release from granules, and the physiological relevance of these processes, remain unclear. The presence of a vesicular matrix appears to create a bi-compartmentalised medium in which the major fractions of solutes, including catecholamines, nucleotides and Ca2+, are strongly associated with vesicle proteins, particularly chromogranins. This association appears to be favoured at acidic pH values. It has been demonstrated that disrupting the pH gradient of secretory vesicles reduces their rate of exocytosis and promotes the leakage of vesicular amines and Ca2+, dramatically increasing the movement of secretory vesicles and triggering exocytosis. In this short review, we will discuss the data available that highlights the importance of pH in regulating the association between chromogranins, vesicular amines and Ca2+. We will also address the potential role of vesicular Ca2+ in two major processes in secretory cells, vesicle movement and exocytosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 51, Issues 3â4, MarchâApril 2012, Pages 338-341
Journal: Cell Calcium - Volume 51, Issues 3â4, MarchâApril 2012, Pages 338-341
نویسندگان
Ricardo Borges, Natalia DomÃnguez, Judith Estévez-Herrera, Daniel Pereda, José David Machado,