کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8463636 | 1549378 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CD11c+ T-bet+ memory B cells: Immune maintenance during chronic infection and inflammation?
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
HClTFHBCRFCRABCsTLRSCIDEMLALPSActivation-induced cytidine deaminaseIOE - بلهdiphtheria toxin - توکسین دیفتریToll-like receptor - تیالآرT follicular helper cell - سلول کمکی فولیکولhairy cell leukemia - لوسمی سلول مویSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکlipopolysaccharide - لیپوپلی ساکاریدGerminal center - مرکز ژرمینالmarginal zone - منطقه حاشیه ایsevere combined immunodeficiency - کمبود شدید مصدومAID - کمکFc receptor - گیرنده FcB cell receptor - گیرنده سلول B
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
CD11c+ T-bet+ B cells have now been detected and characterized in different experimental and clinical settings, in both mice and humans. Whether such cells are monolithic, or define subsets of B cells with different functions is not yet known. Our studies have identified CD11c+ IgM+ CD19hi splenic IgM memory B cells that appear at approximately three weeks post-ehrlichial infection, and persist indefinitely, during low-level chronic infection. Although the CD11c+ T-bet+ B cells we have described are distinct, they appear to share many features with similar cells detected under diverse conditions, including viral infections, aging, and autoimmunity. We propose that CD11c+ T-bet+ B cells as a group share characteristics of memory B cells that are maintained under conditions of inflammation and/or low-level chronic antigen stimulation. In some cases, these cells may be advantageous, by providing immunity to re-infection, but in others may be deleterious, by contributing to aged-associated autoimmune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 321, November 2017, Pages 8-17
Journal: Cellular Immunology - Volume 321, November 2017, Pages 8-17
نویسندگان
Gary M. Winslow, Amber M. Papillion, Kevin J. Kenderes, Russell C. Levack,