MicroRNA signatures of iPSCs and endoderm-derived tissues

► MiRNAs define cell fate changes during reprogramming and differentiation. ► Reprogrammed fibroblasts assumed an ESC-like miRNA signature. ► Activin-A-induced upregulated miRNAs are also highly expressed in pancreatic islets. ► MiRNAs could contribute to differentiation of pluripotent cells towards pancreas.