کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8474830 | 1550433 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of S100 proteins A2 and A6 on cardiac Ca2Â + cycling and contractile performance
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PLNCSQSERCA2aNa+/Ca2 + exchangerNCXRyRCa2 + - Ca2 +Excitation–contraction coupling - تحریک-انقباض جفت شدنSarcomere length - طول سارکومرphospholamban - فسفولامبنLAD - لادوheart failure - نارسایی قلبیS100 proteins - پروتئین S100left anterior descending artery - چپ قوام نزولی شریانGene therapy - ژن درمانیCalsequestrin - کالسهشترینCalcium - کلسیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Defective intracellular calcium (Ca2Â +) handling is implicated in the pathogenesis of heart failure. Novel approaches targeting both cardiac Ca2Â + release and reuptake processes, such as S100A1, have the potential to rescue the function of failing cardiac myocytes. Here, we show that two members of the S100 Ca2Â + binding protein family, S100A2 and S100A6 that share high sequence homology, differentially influence cardiac Ca2Â + handling and contractility. Cardiac gene expression of S100A2 significantly enhanced both contractile and relaxation performance of rodent and canine cardiac myocytes, mimicking the functional effects of its cardiac homologue, S100A1. To interrogate mechanism, Ca2Â + spark frequency, a measure of the gating of the ryanodine receptor Ca2Â + release channel, was found to be significantly increased by S100A2. Therapeutic testing showed that S100A2 rescued the contractile defects of failing cardiac myocytes. In contrast, cardiac expression of S100A6 had no significant effects on contractility or Ca2Â + handling. These data reveal novel differential effects of S100 proteins on cardiac myocyte performance that may be useful in application to diseased cardiac muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 72, July 2014, Pages 117-125
Journal: Journal of Molecular and Cellular Cardiology - Volume 72, July 2014, Pages 117-125
نویسندگان
Wang Wang, Michelle L. Asp, Guadalupe Guerrero-Serna, Joseph M. Metzger,