Myocardial triacylglycerol metabolism

► We summarize our current understanding of myocardial triacylglycerol metabolism. ► We discuss the role of myocardial triacylglycerol turnover in health and disease. ► Adequate triacylglycerol metabolism is important for proper cardiac function. ► Cardiomyocyte lipolysis contributes significantly to cardiac energy metabolism. ► Deranged myocardial triacylglycerol metabolism is associated with cardiac disease.