کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8476723 | 1550843 | 2016 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway
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کلمات کلیدی
IGF-1PEPT2STAT5Janus Kinase 2RIAJAK2ERKASPPI3KHepatocytes - hepatocytesAspartic acid - آسپارتیک اسدAkt - آکتdipeptide - دایپتیکradioimmunoassay - رادیوایمونواسیinsulin-like growth factor 1 - فاکتور رشد مانند انسولین 1signal transducer and activator of transcription 5 - فرستنده سیگنال و فعال کننده رونویسی 5Phosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازPRO - نرم افزارGrowth hormone - هورمون رشدpeptide transporter 1 - پاورپوینت 1protein kinase B - پروتئین کیناز BProline - پرولینPept1 - پپت 1extracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway](/preview/png/8476723.png)
چکیده انگلیسی
It has been implicated that IGF-1 secretion can be regulated by dietary protein. However, whether the dipeptides, one of digested products of dietary protein, have influence on IGF-1 secretion remain largely unknown. Our study aimed to investigate the effects of the dipeptide Pro-Asp on IGF-1 secretion and expression in hepatocytes and to explore the possible underlying mechanisms. Our findings demonstrated that Pro-Asp promoted the secretion and gene expression of IGF-1 in HepG2 cells and primary porcine hepatocytes. Meanwhile, Pro-Asp activated the ERK and Akt signaling pathways, downstream of IGF-1. In addition, Pro-Asp enhanced GH-mediated JAK2/STAT5 signaling pathway, while inhibition of JAK2/STAT5 blocked the promotive effect of Pro-Asp on IGF-1 secretion and expression. Moreover, acute injection of Pro-Asp stimulated IGF-1 expression and activated JAK2/STAT5 signaling pathway in mice liver. Together, these results suggested that the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes by enhancing GH-mediated JAK2/STAT5 signaling pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 436, 15 November 2016, Pages 204-210
Journal: Molecular and Cellular Endocrinology - Volume 436, 15 November 2016, Pages 204-210
نویسندگان
Songbo Wang, Guoqing Wang, Mengyuan Zhang, Lu Zhuang, Xiaojuan Wan, Jingren Xu, Lina Wang, Xiaotong Zhu, Ping Gao, Qianyun Xi, Yongliang Zhang, Gang Shu, Qingyan Jiang,