کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8476932 | 1550864 | 2015 | 21 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histone hypoacetylation and increased histone deacetylases in peripheral blood mononuclear cells from patients with Graves' disease
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کلمات کلیدی
T1DMreal-time quantitative reverse transcriptase PCREP300CREBBPE1A binding protein P300TPOAbPTPN22CTLA4TPOSirt1HLA-DRPBMCsCD40FOXP3SSCRT-PCRHDACHspRheumatoid arthritis - آرتریتروماتوئیدHistone acetylation - استیلیت هیستونAnkylosing spondylitis - اسپوندیلیت انکیلوزانsystemic sclerosis - اسکلروز سیستمیکGraves' disease - بیماری گریوسHistone modifications - تغییرات هیستونThyroid peroxidase - تیروئید پراکسیدازThyroglobulin - تیروگلوبولینforkhead box P3 - جعبه جعبه P3cluster of differentiation 40 - خوشه تمایز 40Type 1 diabetes - دیابت نوع۱peripheral blood mononuclear cells - سلول های تک هسته ای خون محیطیPeripheral blood mononuclear cells (PBMCs) - سلول های تک هسته ای خون محیطی (PBMCs)Systemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکSilent mating type information regulation 2 homolog 1 - مقررات اطلاعات نوع جفت گیری خاموش 2 homolog 1TRAb - نوزادانHenoch–Schönlein purpura - هنوخ-شونلین پورپوراHistone acetyltransferase - هیستون استیل ترانسفرازhistone deacetylase - هیستون داستیلازCREB binding protein - پروتئین اتصال CREBHAT - کلاه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The objective of this study was to investigate histone modification patterns in peripheral blood mononuclear cells (PBMCs) of patients with Graves' disease (GD). Thirty GD patients and 20 healthy controls were enrolled in this study. Global histone H3/H4 acetylation levels of PBMCs in all subjects were detected by enzyme-linked immunosorbent assay. mRNA levels of histone-related chromatin modifier genes were measured by real-time quantitative reverse transcription-polymerase chain reaction. Global histone H4 acetylation level in PBMCs of GD patients was significantly decreased compared with controls (p = 0.005). The mRNA expression of histone deacetylases HDAC1 and HDAC2 were significantly increased in PBMCs of GD patients compared with controls (p = 0.004 and 0.018; respectively). No significant difference was observed either in SIRT1 or in HATs mRNA including p300, CREBBP between GD patients and controls (p > 0.05). Our findings firstly suggested that histone acetylation modifications are aberrant in PBMCs of GD patients, possibly due to the deregulation of epigenetic modifier genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 414, 15 October 2015, Pages 143-147
Journal: Molecular and Cellular Endocrinology - Volume 414, 15 October 2015, Pages 143-147
نویسندگان
Ni Yan, Jiao-zhen Zhou, Jin-an Zhang, Tiantian Cai, Wen Zhang, Yuan Wang, Fatuma-Said Muhali, Lijuan Guan, Rong-hua Song,