کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8477146 | 1550885 | 2014 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A promising approach to iPSC-based cell therapy for diabetic wound treatment: Direct lineage reprogramming
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کلمات کلیدی
MSCsIPSCsNSCsESCsDFUDirect reprogramming - برنامه ریزی مستقیمTransdifferentiation - تمایز متقابلDiabetic wound - زخم دیابتEmbryonic stem cell - سلول های بنیادی جنینیMesenchymal stem cells - سلول های بنیادی مزانشیمیInduced pluripotent stem cells - سلول های بنیادی پرتوان القاییEmbryonic stem cells - سلولهای بنیادی جنینیNeural stem cells - سلولهای بنیادی عصبی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Successful reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has ushered in a new era of regenerative medicine. Several studies on iPSCs have corroborated their immense promise and potential for use in cell therapy and disease modeling. However, several shortcomings need to be overcome before they can be used in clinical therapy. Investigation of iPSC fate and physiology in vivo and ultimately, the feasibility of their application in cell transplantation therapy, requires more in-depth studies in living subjects. One recently established alternative approach to reprogramming involves the direct conversion of a terminally differentiated somatic cell of one type into another, without dedifferentiating into a pluripotent state. This direct lineage reprogramming strategy is significantly faster, has the potential to generate an enriched population of a specific subtype of cells, and hence, has wide implications in regenerative cell therapy. Here, we review recent advances in iPSC technology and summarize the research on the generation of patient-specific induced cell types using direct lineage conversion. Specifically, we focus on the scope of application of this approach in autologous cell replacement therapy for diabetic wound treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 393, Issues 1â2, 5 August 2014, Pages 8-15
Journal: Molecular and Cellular Endocrinology - Volume 393, Issues 1â2, 5 August 2014, Pages 8-15
نویسندگان
Shuang Li, Qin Li,