Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction

► Islets from type 2 diabetic subjects have several transcriptome alterations. ► The ubiquitin-proteasome system (UPS) is deranged in human type 2 diabetic islets. ► Environmental factors can affect islet UPS.