کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8478997 | 1551263 | 2018 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Age-dependent and region-specific alteration of parvalbumin neurons and perineuronal nets in the mouse cerebral cortex
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کلمات کلیدی
S1BFRSGcV2MMV2Lectorhinal cortexLptAPTPRV1bDLOAUVMPTAPRHRSDretrosplenial dysgranular cortexECTAu1Aud - آدمFRA - ازAlzheimer's disease - بیماری آلزایمرAging - سالخوردگیperineuronal nets - شبکه های perineuronalinfralimbic cortex - قشر infralimbicTemporal association cortex - قشر ارتباط موقتیFrontal association cortex - قشر انجمن پیشانیlateral orbital cortex - قشر اوربیتال جانبیdorsolateral orbital cortex - قشر اوربیتال دو طرفهVentral orbital cortex - قشر اوربیتال شکمیprimary motor cortex - قشر حرکتی اولیهsecondary motor cortex - قشر حرکتی ثانویهprimary auditory cortex - قشر شنوایی اولیهcerebral cortex - قشر مغزperirhinal cortex - قشر پریحینالdorsal peduncular cortex - قشر پشتی پشتیprelimbic cortex - قشر پیش از قاعدگیSecondary somatosensory cortex - قشر کمخونی ثانویهMouse - موشParvalbumin - پاروالبومینTEA - چایcingulate cortex - کورتکس کانگولت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cognitive function declines with age. Such function depends on γ-oscillation in the frontal cortex. Pyramidal neurons, and the parvalbumin-expressing interneurons (PV neurons) that control them, are important for the generation of γ-oscillation. The mechanism by which cognitive function declines is unclear. Perineuronal nets (PNNs) mainly surround the soma and proximal dendrites and axon segments of PV neurons in the cerebral cortex. Previous evidence indicates that PNNs inhibit neural plasticity. If this is true, an increase in the number of neurons surrounded by PNNs or in the thickness or density of the PNNs around neurons could decrease plasticity in the cortex. To determine if an aging-related change in cortical PNNs occurs, we examined the influence of aging on PV neurons and whether Wisteria floribunda agglutinin-positive PNNs differ depending on the cortical area. The results showed that the number of PV neurons/mm2 did not change in many areas of the cortex as mice aged. In contrast, the number of neurons in the sensory cortex surrounded by PNNs increased as mice aged. Thus, with age, PNN density increases in some cortical areas but not in others. In addition, the expression level of PV protein in PV neurons decreased with aging in the whole cortex. We suggest that decreased expression of PV protein impairs fast spiking in PV neurons. We propose that PNNs surround more neurons as age increases. This aging-related increase in PNNs decreases plasticity in the cerebral cortex and reduces cognitive function. The first step in investigating this proposal would be to determine if PNN density increases with age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 112, January 2018, Pages 59-70
Journal: Neurochemistry International - Volume 112, January 2018, Pages 59-70
نویسندگان
Hiroshi Ueno, Keizo Takao, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Motoi Okamoto, Shozo Aoki, Takeshi Ishihara,