کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8480076 | 1551369 | 2016 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repression of harmful meiotic recombination in centromeric regions
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کلمات کلیدی
DSBMRNMre11-Rad50-Nbs1CentromeresPSSCSmall interfering RNA - RNA تداخل کوچکsiRNA - siRNAAneuploidy - آنیوپلوئیدی Non-disjunction - بی اختیاریChromosome segregation - جداسازی کروموزومDNA double-strand break - شکست دو رشته DNACrossing-over - عبور از رویMeiosis - میوز Homologous recombination - نوترکیبی همولوگMII - هزار
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Repression of harmful meiotic recombination in centromeric regions Repression of harmful meiotic recombination in centromeric regions](/preview/png/8480076.png)
چکیده انگلیسی
During the first division of meiosis, segregation of homologous chromosomes reduces the chromosome number by half. In most species, sister chromatid cohesion and reciprocal recombination (crossing-over) between homologous chromosomes are essential to provide tension to signal proper chromosome segregation during the first meiotic division. Crossovers are not distributed uniformly throughout the genome and are repressed at and near the centromeres. Rare crossovers that occur too near or in the centromere interfere with proper segregation and can give rise to aneuploid progeny, which can be severely defective or inviable. We review here how crossing-over occurs and how it is prevented in and around the centromeres. Molecular mechanisms of centromeric repression are only now being elucidated. However, rapid advances in understanding crossing-over, chromosome structure, and centromere functions promise to explain how potentially deleterious crossovers are avoided in certain chromosomal regions while allowing beneficial crossovers in others.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 54, June 2016, Pages 188-197
Journal: Seminars in Cell & Developmental Biology - Volume 54, June 2016, Pages 188-197
نویسندگان
Mridula Nambiar, Gerald R. Smith,