کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8485068 | 1551695 | 2018 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human tuberculosis brain promotes neuronal apoptosis but not in astrocytes with high expression of vascular endothelial growth factor
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
The present study aimed to investigate the involvement of the angiogenic marker vascular endothelia growth factor (VEGF) and apoptotic markers of Bcl-2 and Bax in the neurons and astrocytes in the brain infected by Mycobacterium tuberculosis. The immunohistochemistry staining was performed to analyze the expression of the VEGF, Bcl-2 and Bax in the astrocytes and neurons. The expression of VEGF was high in neurons and astrocytes in both the infected brain and control tissues with no difference of angiogenic activity (pâ¯=â¯0.40). Higher Bcl-2 expression was seen in astrocytes of infected brain tissues compared to the control tissues (pâ¯=â¯0.004) promoted a higher anti-apoptotic activity in astrocytes. The neurons expressed strong Bax expression in the infected brain tissues compared to the control tissues (pâ¯<â¯0.001), which indicated more apoptosis in neurons. Thus, neuronal death and survival of infected astrocytes together with high expression of VEGF might be associated with formation of brain tuberculosis. In conclusion, neurons could be more vulnerable than astrocytes in human tuberculosis brain with high expression of VEGF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 112, September 2018, Pages 45-51
Journal: Tuberculosis - Volume 112, September 2018, Pages 45-51
نویسندگان
Fatihah N. Othman, Sangu Muthuraju, Siti Suraiya M. Noor, Sarimah Abdullah, Abdul Aziz Mohd Yusoff, John Tharakan, Shalini Bhaskar, Mohd Shah Mahmood, Fauziah Kassim, Hanip Rafia, Mohd Saffari Mohd Haspani, Azmi Alias, Rogelio H. Pando,