کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8490919 | 1552344 | 2018 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluating flushing procedures to prevent nicarbazin carryover during medicated feed manufacturing
ترجمه فارسی عنوان
ارزیابی روش های شستشو برای جلوگیری از انتقال نیکارابازین در طی تولید خوراک دام خوراکی
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
CFRACNcGMPDNCMRLFDAJECFAOSHAContamination - آلودگیUnited States Food and Drug Administration - اداره غذا و داروی ایالات متحدهDAL - ازAcetonitrile - استونیتریلmetric ton - تن متریک یا تن هزار کیلوییMaximum residue level - حداکثر میزان باقی ماندهMedicated feed - خوراک خوراکیSecond - دومینFlushing - فلاشینگJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذاییCode of Federal Regulations - کد قوانین فدرالhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Carryover of medicated feed additives between batches of feed can potentially result in harmful drug residues in the edible tissues of food-animals. Flushing the equipment with an ingredient, such as ground grain, is one method used to remove any residual medicated feed from the system. It is generally recommended that the quantity of flush used be between 50 and 100â¯g/kg of the mixer's capacity. However, there is little data that supports this recommendation. Therefore, an experiment was conducted to determine the minimum quantity of flush material required to prevent drug carryover; and to quantify the interrelationship between flush size and drug concentration. The feed medicated with nicarbazin (Nicarb 250â¯g/kg®; 00.125â¯g/kg) was manufactured and conveyed from the mixer, through a drag conveyor and bucket elevator, and placed into a finished product bin. The system was then flushed using ground corn in the amount of 25, 50, 100, 150, or 200â¯g/kg of the mixer's capacity (454.5â¯kg). Subsequently, a non-medicated diet was conveyed through the system and samples were collected and analyzed for nicarbazin. No differences were detected among the flush treatments, and all treatments were effective in reducing nicarbazin carryover to less than 2.2â¯mg/kg to the non-medicated diet. Collectively, these studies demonstrate that existing flushing guidelines meet or exceed what is required to prevent carryover of medicated feed additives.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Animal Feed Science and Technology - Volume 242, August 2018, Pages 1-7
Journal: Animal Feed Science and Technology - Volume 242, August 2018, Pages 1-7
نویسندگان
A. Martinez, C.K. Jones, C.R. Stark, L.J. McKinney, K.C. Behnke, C.B. Paulk,