کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8493074 | 1552793 | 2018 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetic study of florfenicol in Bester sturgeon, a cultured hybrid of Huso husoâ¯Ãâ¯Acipenser ruthenus by high performance liquid chromatography equipped with UV detector
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of the study was to develop a simple, rapid, and reliable technique to detect the pharmacokinetics and the residual of florfenicol (FFC) in Bester sturgeon, a cultured hybrid of Huso husoâ¯Ãâ¯Acipenser ruthenus by high performance liquid chromatography (HPLC) with UV detector. The results showed that the concentration-time course of the FFC was described by one-compartment model with 1st order absorption in the blood. The retention time of FFC was 7.3â¯min. The limit of detection of FFC concentration using our developed method was 0.01â¯mgâ¯kgâ1 BW. After given single dose 10â¯mgâ¯kgâ1 BW per day of FFC via oral administration for sturgeon, the main pharmacokinetic parameters in blood were found as following: Cmax (maximum concentration) was 10.9568â¯Î¼gâ¯mLâ1, Tmax (time to Cmax) was 10â¯h, AUC (area under the curve) was 251.064â¯Î¼gâ¯Ãâ¯hrâ¯mLâ1, t1/2 (half-life) was 12.1301â¯h, CL (total body clearance) was 0.0387â¯Lâ¯kgâ1, V/F (apparent volume of distribution) was 0.6777â¯Lâ¯kgâ1, and MRT (the mean residence time) was 23.7431â¯h. Additionally, the concentration-time course of the FFC was also described by two-compartment model with 1st order absorption in the muscle and liver. The recoveries of muscle and liver from sturgeon were 92-108% and 90-104%, respectively. Taken together, the results showed that the developed method technique may be a valuable tool was efficient in detecting the pharmacokinetics of FFC in Bester sturgeon.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquaculture - Volume 495, 1 October 2018, Pages 558-567
Journal: Aquaculture - Volume 495, 1 October 2018, Pages 558-567
نویسندگان
Yu-Wen Hung, Yu-Hsing Lin, Ming-Hui Chen, Way-Shyan Wang, Ching-Feng Chiu, Chien-Chao Chiu, Hsuan-Wen Chiu, Wei-Huang Tsai, Shao-Wen Hung,