کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8504036 | 1554294 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of lipid profiles in serum of obese ponies before and after weight reduction by using multi-one-dimensional thin-layer chromatography
ترجمه فارسی عنوان
تعیین پروفایل لیپید در سرم پونه چاق قبل و بعد از کاهش وزن با استفاده از کروماتوگرافی لایه نازک چند بعدی
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کلمات کلیدی
NEFAEMSLPCFFAHorse - اسبsphingomyelin - اسفنگومیلینFree fatty acid - اسید چرب آزادNon-esterified fatty acid - اسید چرب غیر استرادیلیtriacylglycerol - تری آسیل گلیسرول intra venous - داخل وریدیCNS - دستگاه عصبی مرکزیBCs - روند BCsEquine metabolic syndrome - سندرم متابولیک اسبphosphatidylcholine - فسفاتیدیل کولینphosphatidylethanolamine - فسفاتیدیلتانولامینPhosphatidylserine - فسفاتیدیلسرینPhospholipids - فسفولیپیدLysophosphatidylcholine - لیزوفسفاتیدیل کولینneutral lipid - لیپید خنثیneutral lipids - لیپید های خنثیInsulin resistant - مقاوم در برابر انسولینBody condition score - نمره وضعیت بدنbody weight - وزن بدنCardiolipin - کاردیولیپینthin layer chromatography - کروماتوگرافی لایه نازکcholesterol - کلسترولCholesterol ester - کلسترول استر
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Obesity is a key component of equine metabolic syndrome, which is highly associated with laminitis. Feed restriction and/or exercise are known to alleviate the detrimental effects of insulin resistance in obese ponies. However, little is known about changes in the serum lipid patterns due to weight reduction and its association with disease outcomes. Therefore, the lipid patterns in the serum of 14 mature ponies before and after a 14-week body weight reduction program (BWRP) were investigated by multi-one-dimensional thin-layer chromatography (MOD-TLC). Additionally, sensitivity to insulin (SI), body condition scores (BCS) and cresty neck scores (CNS) were measured. A BWRP resulted in a significant loss of body weight (PÂ <Â 0.001), which was associated with beneficial decreases in BCS and CNS (both, PÂ <Â 0.001). Serum lipid compositions revealed significantly increased free fatty acid (FFA), sphingomyelin (SM; both PÂ <Â 0.001), total cholesterol (C) and cholesterol ester (CE) (both PÂ <Â 0.01) and triacylglycerol (TG; PÂ <Â 0.05) densities. Improvement of SI after the BWRP was associated with increases in neutral lipids (C, CE and TG, all PÂ <Â 0.01), FFA and the phospholipid SM (both, PÂ <Â 0.001). The results show that a BWRP in obese ponies was effective and associated with changes in the concentrations of neutral lipids and the phospholipid SM, indicating that SM may play a role in insulin signaling pathways and thus in the pathogenesis of insulin resistance and the progression of metabolic syndrome in obese ponies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 117, April 2018, Pages 111-117
Journal: Research in Veterinary Science - Volume 117, April 2018, Pages 111-117
نویسندگان
Ratchada Auyyuenyong, Andrea Henze, Julia Ungru, Florian J. Schweigert, Jens Raila, Ingrid Vervuert,