Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents

Twenty-six new tricyclic matrinic derivatives were designed, synthesized and evaluated for their activities against Ebola virus in vitro using a pHIV-EBOVGP-Fluc model. Compound 7d exhibited better in vivo anti-EBOV and anti-MARV effects than the positive control sertraline. The results suggested its inspiring broad-spectrum anti-filovirus activity.237