کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513305 | 1556493 | 2018 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis
ترجمه فارسی عنوان
چشم هالوژن اکونازول هیدروژل برای درمان کراتیت قارچی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Econazole is a feasible alternative treatment in the management of fungal keratitis. Nevertheless, its low water solubility is considered the main limitation to the incorporation into ophthalmic formulations. In this work, econazole nitrate is solubilized by using cyclodextrins to achieve an optimum therapeutic concentration. Phase solubility diagrams suggest α-cyclodextrin as the most effective cyclodextrin and later the inclusion complex formed with this one was characterized in solution by 1D, 2D-NMR, and molecular modeling. Econazole-α-cyclodextrin inclusion complex was included in 2 types of ocular hydrogels: a natural polysaccharides ion-sensitive hydrogel and a hyaluronic acid hydrogel. Both of them show no ocular irritation in the hen's egg test on chorioallantoic membrane assay and a controlled econazole release over time. Permeability studies suggest that hydrogels do not modify the econazole nitrate permeability through bovine cornea in comparison with an econazole-α-cyclodextrin inclusion complex solution. Finally, ocular biopermanence studies performed using positron emission tomography show these hydrogels present a high retention time on the eye. Results suggest the developed formulations have a high potential as vehicles for the econazole topical ocular administration as fungal keratitis treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 5, May 2018, Pages 1342-1351
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 5, May 2018, Pages 1342-1351
نویسندگان
Victoria DÃaz-Tomé, Andrea Luaces-RodrÃguez, Jesús Silva-RodrÃguez, Sara Blanco-Dorado, Laura GarcÃa-Quintanilla, José Llovo-Taboada, José Blanco-Méndez, Xurxo GarcÃa-Otero, Rubén Varela-Fernández, Michel Herranz, MarÃa Gil-MartÃnez,