کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8513380 1556494 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thermodynamic Estimate of the Number of Solvent Molecules Displaced by a Solute Molecule for Enthalpy-Driven Adsorption: Phenobarbital and Activated Carbons as the Model System
ترجمه فارسی عنوان
برآورد ترمودینامیکی تعداد مولکول های حلال جایگزین شده توسط مولکول حل شده برای جذب اتانول: فنوباربیتال و کربن فعال به عنوان سیستم مدل
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی
A Modified Crisp Equation, describing the differential Gibbs free energy of the adsorption process, is being proposed, which considers multiple sites available on the surface for adsorption and their relative fractions. The differential Gibbs free energy can be calculated by the van't Hoff Equation, which depends on the affinity constant in the Langmuir-like equation. To consider the number of solvent molecules displaced by a solute molecule in the adsorption process, a new derivative of the Langmuir-like equation is being proposed as well. By comparing the differential Gibbs free energies obtained from the 2 thermodynamic relationships, it can be determined that a phenobarbital molecule displaces 5 water molecules on the activated carbon surface for site-specific adsorption from solution. For the series of experimental conditions studied, including 4 activated carbons, pH effects, temperature effects, and solvent effects, the corrected differential Gibbs free energies using n1 = 5 for site-specific adsorption are quite consistent between the 2 thermodynamic relationships. The difference between the estimates of the differential Gibbs free energies by the Modified Crisp Equation and the van't Hoff Equation provides a new experimental method to calculate the number of solvent molecules displaced by an adsorbing solute molecule.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 4, April 2018, Pages 1055-1062
نویسندگان
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