کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514456 | 1556507 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High-Throughput Fabrication of Nanocomplexes Using 3D-Printed Micromixers
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کلمات کلیدی
PDIPDMSThree-dimensionalMicrofluidicsPSSMicromixerPDDAHigh throughput - توان بالاContinuous manufacturing - تولید مداومpolydispersity index - شاخص پلییدریزاییNanoparticles - نانوذراتNanocomplex - نانوکامپپل3D printing - پرینت سه بعدیpoly(diallyldimethylammonium chloride) - پلی (دی آلدیل متیل آمونیوم کلرید)poly(dimethylsiloxane) - پلی (دی متیل سیلوکسان)Poly(sodium 4-styrenesulfonate) - پلی (سدیم 4-استیرنسولفونات)
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
3D printing allows a rapid and inexpensive manufacturing of custom made and prototype devices. Micromixers are used for rapid and controlled production of nanoparticles intended for therapeutic delivery. In this study, we demonstrate the fabrication of micromixers using computational design and 3D printing, which enable a continuous and industrial scale production of nanocomplexes formed by electrostatic complexation, using the polymers poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate). Several parameters including polymer concentration, flow rate, and flow ratio were systematically varied and their effect on the properties of nanocomplexes was studied and compared with nanocomplexes prepared by bulk mixing. Particles fabricated using this cost effective device were equally small and homogenous but more consistent and controllable in size compared with those prepared manually via bulk mixing. Moreover, each micromixer could process more than 2 liters per hour with unaffected performance and the setup could easily be scaled-up by aligning several micromixers in parallel. This demonstrates that 3D printing can be used to prepare disposable high-throughput micromixers for production of therapeutic nanoparticles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 3, March 2017, Pages 835-842
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 3, March 2017, Pages 835-842
نویسندگان
Adam Bohr, Johan Boetker, Yingya Wang, Henrik Jensen, Jukka Rantanen, Moritz Beck-Broichsitter,