کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514458 | 1556507 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Full Out-of-Die Compressibility and Compactibility Profiles From Two Tablets
ترجمه فارسی عنوان
کامل فشرده سازی فشرده سازی و پروفیل های سازگاری از دو قرص
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کلمات کلیدی
فشرده سازی، تراکم ویژگی های مکانیکی، تکنولوژی پودر، قرص قرص
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
In this study, a method is presented that can be used to generate full out-of-die compressibility and compactibility profiles using the data from only 2 tablets. For each material, one tablet was compacted at the maximum pressure of interest and a second tablet at a relatively low pressure. The in-die data collected during compaction to the maximum pressure of interest and the solid fraction change after ejection for both tablets were used to generate a profile equivalent to a complete out-of-die compressibility profile. After measuring the tensile strengths of each tablet, a compactibility profile was produced by fitting the out-of-die porosity and tensile strength data to the Ryshkewitch-Duckworth equation. This method generated accurate out-of-die compressibility and compactibility profiles for each of the materials studied. Not only is this technique computationally simple, but in cases where only small amounts of raw material are available, this method allows a detailed understanding of a material's mechanical behavior to be assessed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 3, March 2017, Pages 843-849
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 3, March 2017, Pages 843-849
نویسندگان
Jeffrey M. Katz, Ira S. Buckner,