کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514595 | 1556509 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Atmospheric Spray Freeze-Drying: Numerical Modeling and Comparison With Experimental Measurements
ترجمه فارسی عنوان
فریزر جوش اسپری: مدل سازی عددی و مقایسه آن با اندازه گیری های تجربی
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کلمات کلیدی
اسپری یخ خشک کردن، ترمودینامیک، شبیه سازی، پروتئین ها، انجماد خشک / لیوفیلیزاسیون، تکنولوژی پودر، مدل ریاضی،
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Atmospheric spray freeze-drying (ASFD) represents a novel approach to dry thermosensitive solutions via sublimation. Tests conducted with a second-generation ASFD equipment, developed for pharmaceutical applications, have focused initially on producing a light, fine, high-grade powder consistently and reliably. To better understand the heat and mass transfer physics and drying dynamics taking place within the ASFD chamber, 3 analytical models describing the key processes are developed and validated. First, by coupling the dynamics and heat transfer of single droplets sprayed into the chamber, the velocity, temperature, and phase change evolutions of these droplets are estimated for actual operational conditions. This model reveals that, under typical operational conditions, the sprayed droplets require less than 100Â ms to freeze. Second, because understanding the heat transfer throughout the entire freeze-drying process is so important, a theoretical model is proposed to predict the time evolution of the chamber gas temperature. Finally, a drying model, calibrated with hygrometer measurements, is used to estimate the total time required to achieve a predefined final moisture content. Results from these models are compared with experimental data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 1, January 2017, Pages 183-192
Journal: Journal of Pharmaceutical Sciences - Volume 106, Issue 1, January 2017, Pages 183-192
نویسندگان
Israel Borges Sebastião, Thomas D. Robinson, Alina Alexeenko,