کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8514754 1556511 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-Phase and Oscillating Solution Crystallization Behavior of (+)- and (−)-N-Methylephedrine
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
پیش نمایش صفحه اول مقاله
Solid-Phase and Oscillating Solution Crystallization Behavior of (+)- and (−)-N-Methylephedrine
چکیده انگلیسی
This work involves the study of the solid-phase and solution crystallization behavior of the N-methylephedrine enantiomers. A systematic investigation of the melt phase diagram of the enantiomeric N-methylephedrine system was performed considering polymorphism. Two monotropically related modifications of the enantiomer were found. Solubilities and the ternary solubility phase diagrams of N-methylephedrine enantiomers in 2 solvents [isopropanol:water, 1:3 (Vol) and (2R, 3R)-diethyl tartrate] were determined in the temperature ranges between 15°C and 25°C, and 25°C and 40°C, respectively. Preferential nucleation and crystallization experiments at higher supersaturation leading to an unusual oscillatory crystallization behavior as well as a successful preferential crystallization experiment at lower supersaturation are presented and discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 11, November 2016, Pages 3359-3365
نویسندگان
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