کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8514915 | 1556513 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solution and Solid State Nuclear Magnetic Resonance Spectroscopic Characterization of Efavirenz
ترجمه فارسی عنوان
تشخیص اسپکتروسکوپی رزونانس مغناطیسی هسته ای محلول و حالت جامد ایفایو ارنز
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
Samples of efavirenz (EFZ) were evaluated to investigate the influence of the micronization process on EFZ stability. A combination of X-ray diffraction, thermal analysis, FTIR, observations of isotropic chemical shifts of 1H in distinct solvents, their temperature dependence and spin-lattice relaxation time constants (T1), solution (1D and 2D) 13C nuclear magnetic resonance (NMR), and solid-state 13C NMR (CPMAS NMR) provides valuable structural information and structural elucidation of micronized EFZ and heptane-recrystallized polymorphs (EFZ/HEPT). This study revealed that the micronization process did not affect the EFZ crystalline structure. It was observed that the structure of EFZ/HEPT is in the same form as that obtained from ethyl acetate/hexane, as shown in the literature. A comparison of the solid-state NMR spectra revealed discrepancies regarding the assignments of some carbons published in the literature that have been resolved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 9, September 2016, Pages 2656-2664
Journal: Journal of Pharmaceutical Sciences - Volume 105, Issue 9, September 2016, Pages 2656-2664
نویسندگان
Eduardo Gomes Rodrigues de Sousa, Erika Martins de Carvalho, Rosane Aguiar da Silva San Gil, Tereza Cristina dos Santos, Leandro Bandeira Borré, Osvaldo Andrade Santos-Filho, Javier Ellena,