کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8516948 | 1556584 | 2018 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Conditional inactivation of Npy1r gene in mice induces behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram
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کلمات کلیدی
NPY5-hydroxytriptamineWater T-mazeMWMOFCOCD5-HTc-fosPaVNGSα-CaMKIIPBSWTMY1RNPY1RCREBLAbasolateral amygdala - amygdala basolateralobsessive-compulsive disorder - اختلال وسواس فکری یا عملیBehavioural flexibility - انعطاف پذیری رفتاریImmunoreactivity - ایمنی فعالCNS - دستگاه عصبی مرکزیdigoxigenin - دیگوکسین ژنpostnatal day - روز پس از زایمانnormal goat serum - سرم طبیعی بزcentral nervous system - سیستم عصبی مرکزیDIG - شماPhosphate buffered saline - فسفات بافر شورorbitofrontal cortex - قشر اوربیتوفرنتالMorris water maze - ماز آب آب موریسselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینEscitalopram - همزمان escitalopramParvalbumin - پاروالبومینoptical density - چگالی نوریCre recombinase - کرم recombinaseY1 receptor - گیرنده Y1Y5 receptor - گیرنده Y5Neuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cognitive flexibility is the ability to rapidly adapt established patterns of behaviour in the face of changing circumstance and depends critically on the orbitofrontal cortex (OFC). Impaired flexibility also results from altered serotonin transmission in the OFC. The Y1 (Y1R) and Y5 (Y5R) receptors for neuropeptide Y (NPY) colocalize in several brain regions and have overlapping functions in regulating cognition and emotional behaviour. The targeted disruption of gene encoding Y1R (Npy1r gene) in Y5R containing neurons (Npy1rY5Râ/â mice) increases anxiety-like behaviour and spatial reference memory. Here we used the same conditional system to analyse whether the coordinated expression of the Y1R and Y5R might be required for behavioural flexibility in reversal learning tasks, OFC serotoninergic tone and OFC neural activity, as detected by immunohistochemical quantification of the immediate-early gene, c-Fos. In addition, we investigated whether the acute treatment of Npy1rY5Râ/â mice with the selective serotonin reuptake inhibitor escitalopram affected behavioural flexibility and OFC c-Fos expression. Npy1rY5Râ/â male mice exhibit an impairment in performing the reversal task of the Morris water maze and the water T-maze but normal spatial learning, working memory and sociability, compared to their control siblings. Furthermore, Npy1rY5Râ/â male mice display decreased 5-hydroxytriptamine (5-HT) positive fibres and increased baseline neural activity in OFC. Importantly, escitalopram normalizes OFC neural activity and restores behavioural flexibility of Npy1rY5Râ/â male mice. These findings suggest that the inactivation of Y1R in Y5R containing neurons increases pyramidal neuron activity and dysregulates serotoninergic tone in OFC, whereby contributing to reversal learning impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 133, 1 May 2018, Pages 12-22
Journal: Neuropharmacology - Volume 133, 1 May 2018, Pages 12-22
نویسندگان
Angela Longo, Melissa Fadda, Claudio Brasso, Paolo Mele, Paola Palanza, Ishira Nanavaty, Ilaria Bertocchi, Alessandra Oberto, Carola Eva,