کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8526186 | 1557946 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
DNA is considered one of the most promising targets of molecules with anticancer activity potential. Its key role in various cell division mechanisms, which commands the intense multiplication of tumor cells, is considered in studies with compounds whose mechanisms of action suggest likeliness of interaction. In addition, inhibition of enzymes that actively participate in biological functions of cells such as Topoisomerase, is seen as a primary factor for conducting several events that result in cell death. Discovery of new anticancer chemotherapeutical capable of interacting with DNA and inhibiting Topoisomerase enzymes is highlighted in anticancer research. The present review aims at showing through distinct biological tests the performance of different candidates to anticancer drugs and their respective chemical modifications, which are crucial and/or determinant for DNA affinity and inhibition of important enzymes in cells' vital processe to either separately or synergistically optimize anticancer activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Pharmacotherapy - Volume 96, December 2017, Pages 1538-1556
Journal: Biomedicine & Pharmacotherapy - Volume 96, December 2017, Pages 1538-1556
نویسندگان
Sinara Mônica Vitalino de Almeida, Amélia Galdino Ribeiro, Geilza Carla de Lima Silva, Josival Emanuel Ferreira Alves, Eduardo Isidoro Carneiro Beltrão, Jamerson Ferreira de Oliveira, Luiz Bezerra Junior, Maria do Carmo Alves de Lima,