کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8528536 1558105 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pluripotent stem cell replacement approaches to treat type 1 diabetes
ترجمه فارسی عنوان
روش های جایگزینی سلول های بنیادی چندگانه برای درمان دیابت نوع 1
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
Stem cells represent a potential candidate for β cell replacement in type 1 diabetes. Pluripotent stem cells are able to differentiate in vitro into functional insulin producing cells, that can restore normoglycemia in diabetic mice. Clinical trials with embryonic stem cell-derived pancreatic progenitors are ongoing. Besides, induced pluripotent stem cells offer the chance of personalized cell therapy. So far, transition to the clinic still needs to face critical issues, such as immunogenicity and safety of stem cell derived β cells. To this purpose, new strategies for immunoprotection, including micro and macro-encapsulation, but also gene editing approaches, are being explored.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 43, December 2018, Pages 20-26
نویسندگان
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