کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8528580 1558107 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of the plant-derived peptide lunasin as an anticancer agent
ترجمه فارسی عنوان
توسعه لنزین پپتید مشتق شده از گیاه به عنوان عامل ضد سرطان
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
The health benefits of soy consumption have long been recognized. An important potential benefit is the linkage of soy consumption with reduced cancer risk. One emerging factor that may confer the anticancer effects of soy is the peptide lunasin. Lunasin has both chemopreventive and therapeutic activities against a variety of carcinogens and cancer types. A novel feature of lunasin is that it contains multiple functional domains that can modulate gene expression through effects on histone acetylation and integrin signaling. Recent studies suggest that lunasin effects on integrin signaling in cancer stem cells reduce expression of stemness factors with a concomitant reduction in metastatic potential. Here, we highlight recent studies of the potential use of lunasin as an anticancer agent and its mode of action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 41, August 2018, Pages 27-33
نویسندگان
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