کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8528611 1558108 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities
ترجمه فارسی عنوان
هدف قرار دادن متابولیسم آرگوناز و اکسید نیتروژن در بیماری های مزمن و همراهی آنها
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
In the airways, arginase and NOS compete for the common substrate l-arginine. In chronic airway diseases, such as asthma and COPD, elevated arginase expression contributes to airway contractility, hyperresponsiveness, inflammation and remodeling. The disrupted l-arginine homeostasis, through changes in arginase and NOS expression and activity, does not only play a central role in the development of various airways diseases such as asthma or COPD. It possibly also affects l-arginine homeostasis throughout the body contributing to the emergence of co-morbidities. This review focusses on the role of arginase, NOS and ADMA in co-morbidities of asthma and COPD and speculates on their possible connection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 40, June 2018, Pages 126-133
نویسندگان
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