کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8528758 1558112 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The application of in vitro surveillance data for antibacterial dose selection
ترجمه فارسی عنوان
استفاده از داده های نظارت در آزمایشگاهی برای انتخاب دوز ضد باکتری
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی
In vitro surveillance data, which provide key information to interpret the results of pharmacokinetic/pharmacodynamics (PK-PD) target attainment studies, are used to support dose selection decisions and recommendations for in vitro susceptibility testing criteria for antibacterial agents during drug development. Considerations for designing the in vitro surveillance database to support the development of antibacterial agents include the choice of pathogens to study, the sample size of isolate collections needed, and target patient populations from which clinical isolates should be collected. Post-approval, global in vitro surveillance data produced by reference quality antibacterial susceptibility tests together with PK-PD target attainment analyses provide the opportunity to evaluate approved and clinically used antibacterial dosing regimens. These data enable the optimal use of antibacterial agents in an environment in which we face changing and challenging bacterial pathogens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Pharmacology - Volume 36, October 2017, Pages 130-138
نویسندگان
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