Calcium sensing receptor expression and signalling in cardiovascular physiology and disease

Physiological agonists of the CaSR are different cationic molecules. Acute effects on cells of the cardiovascular system include vasodilatory effects on the level of endothelial and smooth muscle cells as well as improvement of cardiac inotropy. Please notice, that chronic activation of CaSR exerts different actions that may become mal-adaptive (see text for details).129