کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545719 | 1561682 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells
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کلمات کلیدی
DMEMRPMI mediumPCB 52OH-PCBDPBSHSAPCB3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromide4-Chlorobiphenyl - 4-کلروبیفنیلMTT - MTThuman serum albumin - آلبومین سرم انسانیPolychlorinated biphenyl - بیفنیل پلی کربناتhorse serum - سرب اسبNeurotoxicity - سمیت عصبیHepatotoxicity - سمیت کبدDulbecco’s phosphate buffered saline - فسفات باسیل نمک Dulbeccolactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Dulbecco’s modified eagle’s medium - محیط عقاب اصلاح شده DulbeccoRoswell Park Memorial Institute medium - موسسه خاطرات Roswell Park mediumhydroxylated polychlorinated biphenyl - هیدروکسید پلی فنل بفنیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells](/preview/png/8545719.png)
چکیده انگلیسی
Although neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lines (N27 and SH-SY5Y) and an hepatic cell line (HepG2). With the exception of a similar toxicity seen for N27 cells exposed to either OH-PCB 52 or PCB 52 sulfate, these OH-PCBs were more toxic to all three cell-types than their corresponding PCB or PCB sulfate congeners. Differences in the distribution of individual OH-PCB and PCB sulfate congeners between the cells and media, and the ability of cells to interconvert PCB sulfates and OH-PCBs, were important components of cellular sensitivity to these toxicants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 69-78
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 69-78
نویسندگان
Eric A. Rodriguez, Brigitte C. Vanle, Jonathan A. Doorn, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. Duffel,