کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545719 | 1561682 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DMEMRPMI mediumPCB 52OH-PCBDPBSHSAPCB3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromide4-Chlorobiphenyl - 4-کلروبیفنیلMTT - MTThuman serum albumin - آلبومین سرم انسانیPolychlorinated biphenyl - بیفنیل پلی کربناتhorse serum - سرب اسبNeurotoxicity - سمیت عصبیHepatotoxicity - سمیت کبدDulbecco’s phosphate buffered saline - فسفات باسیل نمک Dulbeccolactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Dulbecco’s modified eagle’s medium - محیط عقاب اصلاح شده DulbeccoRoswell Park Memorial Institute medium - موسسه خاطرات Roswell Park mediumhydroxylated polychlorinated biphenyl - هیدروکسید پلی فنل بفنیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Although neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity of OH-PCBs and PCB sulfates derived from PCBs 3, 8, 11, and 52 in two neural cell lines (N27 and SH-SY5Y) and an hepatic cell line (HepG2). With the exception of a similar toxicity seen for N27 cells exposed to either OH-PCB 52 or PCB 52 sulfate, these OH-PCBs were more toxic to all three cell-types than their corresponding PCB or PCB sulfate congeners. Differences in the distribution of individual OH-PCB and PCB sulfate congeners between the cells and media, and the ability of cells to interconvert PCB sulfates and OH-PCBs, were important components of cellular sensitivity to these toxicants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 69-78
Journal: Environmental Toxicology and Pharmacology - Volume 62, September 2018, Pages 69-78
نویسندگان
Eric A. Rodriguez, Brigitte C. Vanle, Jonathan A. Doorn, Hans-Joachim Lehmler, Larry W. Robertson, Michael W. Duffel,