کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545947 | 1561684 | 2018 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats
ترجمه فارسی عنوان
دوزهای پایین مسمومیت متیل کرچک به تنهایی یا با مصرف نوشیدن الکل با الکل، باعث اختلالات روانپزشکی در موش های صحرایی نر و ماده می شود
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کلمات کلیدی
متیل کرچک، اتانول، بلوغ، رفتار - اخلاق، موش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Methylmercury (MeHg) is an environmental contaminant that provokes damage to developing brain. Simultaneously, the consumption of ethanol among adolescents has increased. Evidence concerning the effects of MeHg low doses per se or associated with ethanol during adolescence are scarce. Thus, we investigate behavioral disorders resulted from exposure to MeHg low doses and co-intoxicated with ethanol in adolescent rats. Wistar rats received chronic exposure to low doses of MeHg (40â¯Î¼g/kg/day for 5 weeks) and/or ethanol binge drinking (3â¯g/kg/day at 3 days per week for 5 weeks). Animals were submitted to behavioral assays to assess emotionality and cognitive function. Total mercury content was evaluated in the brain and hair. Oxidative parameters were analyzed in blood samples. MeHg at low doses or associated to ethanol binge drinking produced psychiatric-like disorders and cognitive impairment. Peripherally, MeHg altered oxidative parameters when associated to ethanol. Ethanol administration reduced brain mercury deposit. We proposed that ethanol reduces the necessity of mercury tissue levels to display psychiatric-like disorders/cognitive impairment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 60, June 2018, Pages 184-194
Journal: Environmental Toxicology and Pharmacology - Volume 60, June 2018, Pages 184-194
نویسندگان
Ivaldo Jesus Almeida Belém-Filho, Paula Cardoso Ribera, Aline Lima Nascimento, Antônio Rafael Quadros Gomes, Rafael Rodrigues Lima, Maria Elena Crespo-Lopez, Marta Chagas Monteiro, Enéas Andrade Fontes-Júnior, Marcelo Oliveira Lima,