کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545971 | 1561685 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP)
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کلمات کلیدی
NSAIDSMRODCYP1A1ERODH4IIEH4IIE cellsGPXGSTCATCOXSTP - PTSethoxyresorufin O-deethylase - اتoxyresorufin O-دی اتیلازEnantiomer - انانتیومورOxidative stress - تنش اکسیداتیوNon-steroidal anti-inflammatory drugs - داروهای ضد التهابی غیر استروئیدیDexketoprofen - دکستاپوپروفنBiotransformation - زیستدگرگونیcytochrome P450 1A1 - سیتوکروم P450 1A1Cyclooxygenases - سیکلوکوکسی ...Catalase - کاتالازketoprofen - کتوپروفنglutathione S-transferase - گلوتاتیون S-ترانسفرازglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازSewage treatment plants - گیاهان فاضلاب
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Pharmaceuticals such as racemate ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP) are highly detectable non-steroidal anti-inflammatory drugs (NSAIDs) in the aquatic environment and therefore are designated as one of the most emerging groups of pollutants that can affect environmental and human health. The potential impact of these pharmaceuticals was assessed for the first time in vitro using a rat hepatocellular carcinoma cell line (H4IIE). Cells were exposed to low and high concentrations of these drugs. Cytotoxicity was determined by MTT reduction assay; CYP1A1 transcriptional and enzymatic levels together with canonical oxidative stress responsive markers (GPx, GR, GST and CAT) were also investigated. Cells exposed to RS-KP and S(+)-KP did not show cytotoxicity effect at the concentrations tested. However, this study highlighted differences between RS-KP and S(+)-KP in most of the evaluated markers, showing compound-, concentration- and time-specific effect patterns which suggest a potential stereo-selective toxicity of these drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 59, April 2018, Pages 199-207
Journal: Environmental Toxicology and Pharmacology - Volume 59, April 2018, Pages 199-207
نویسندگان
Elvira Mennillo, Ã
se Krøkje, Carlo Pretti, Valentina Meucci, Augustine Arukwe,