کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
8550372 1562030 2018 23 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Manganese and neurobehavioral impairment. A preliminary risk assessment
ترجمه فارسی عنوان
منگنز و اختلالات عصبی رفتاری. ارزیابی خطر اولیه
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موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Similar patterns of cognitive and motor deficits have been widely reported from manganese exposures in welding, metallurgical and chemical industry workers. A risk assessment was performed based on studies reported in the literature, extending some earlier work, and deriving new estimates of exposure response and excess risk. Many investigations of manganese neurological effects in humans have insufficient information to derive an exposure response; however, findings from a chemical manufacturer, two smelter and two welder populations permitted application of the benchmark dose procedure for continuous end-points. Small particles and aggregates of condensation fume (condensing vaporized metal, <0.1 μm in diameter) appear to have a higher potency per unit mass than larger particles from dusts (>1.0 μm). Consideration was given to long-term effects of continuous low exposures that instead of producing increasing toxicity attain a steady-state condition. Impairment was defined as excursions beyond the 5th percentile in a normal population and the concentrations of manganese predicted to result in 1% excess prevalence of impairment over different time periods were calculated. Over five years, exposures resulting in 1% excess prevalence of impairment (for purposes of discussion) were in the vicinity of 10 μg/m3 for manganese fume and 25 μg/m3 for larger particle dusts. These levels are below current recommendations for occupational limits on manganese exposure in the United States.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 64, January 2018, Pages 159-165
نویسندگان
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