کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550697 | 1562072 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Behavioral impairments following repeated intranasal glyphosate-based herbicide administration in mice
ترجمه فارسی عنوان
اختلالات رفتاری ناشی از تزریق علف کش مبتنی بر گلیفواسات مکرر در موش ها
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Inhalation or intranasal (IN) administration of neurotoxicants could constitute a route of toxin delivery to the brain. Pesticides have been proposed as the main environmental factor associated with the etiology of neurodegenerative disorders. In Argentina, the area used for glyphosate (Gly)-resistant crops are sprayed annually with ~Â 200 million liters of Gly-based herbicides (Gly-BHs). Gly residues are often found in the environment, and considering the frequency and amount of its applications, it is probable that the inhalation of Gly-BHs occurs. The present study investigates the neurobehavioral effects of repeated IN administration of Gly-BH in male CF-1 mice (~Â 2Â mg/nostrils/day) three days a week, during four weeks (50Â mg/kg/day). Locomotor activity and anxiety levels were studied by the Open Field (OF) test. Anxiety was also analyzed through the plus maze (PM) test. Novel Object Recognition (NOR) test was used for recognition memory analysis. Repeated IN Gly-BH administration in mice decreased the ambulatory activity. Moreover, Gly-BH treated mice showed a pronounced increase in thigmotaxis, compared to control group, indicating higher anxiety levels. The anxiogenic behavior in Gly-BH treated mice was then confirmed by PM test. The recognition memory was significantly impaired after 6Â h in the Gly-BH treated group. No differences were observed between both groups when the NOR test was performed 24Â h after. The present study reveals that repeated IN exposure to Gly-BH in mice affects the central nervous system probably altering neurotransmission pathways that participate or regulate locomotor activity, anxiety and memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 64, November 2017, Pages 63-72
Journal: Neurotoxicology and Teratology - Volume 64, November 2017, Pages 63-72
نویسندگان
Carlos Javier Baier, Cristina Eugenia Gallegos, Rita Raisman-Vozari, Alejandra Minetti,