کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8551044 1562106 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of the exposure to harmful and potentially harmful constituents in healthy Japanese smokers using a novel tobacco vapor product compared with conventional cigarettes and smoking abstinence
ترجمه فارسی عنوان
ارزیابی قرار گرفتن در معرض مواد مضر و بالقوه مضر در افراد سیگاری سالم ژاپنی با استفاده از یک تار موی جدید بخار در مقایسه با سیگار معمول و سستی سیگار
کلمات کلیدی
مطالعه بالینی، رطوبت محصول تنباکو، سیگاری سالم بالغ ژاپنی، مواد مضر و بالقوه مضر، بیومارکرهای قرار گرفتن در معرض،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
The objectives of this clinical study were to demonstrate a reduction in exposure to selected harmful and potentially harmful constituents (HPHCs), and to assess product use behavior, in Japanese healthy adult smokers who switched to a novel tobacco vapor product (NTV). 60 smokers were randomly assigned for 5 days to either (a) a group who switched to an NTV (n = 20), (b) a group who continued to smoke their own brand of conventional cigarettes (CC, n = 20) or (c) a smoking abstinence group (SA, n = 20). Fifteen biomarkers of exposure (BoEs) to 14 HPHCs and pyrene were measured at baseline, day 3 and 5. Product use behavior was assessed by measuring product consumption, nicotine uptake and puffing topography. During investigations, increases were observed in product consumption and total puff volume in NTV group subjects as compared to baseline. Additionally, nicotine uptake in the NTV group was approximately half that observed in the CC group. BoE values were significantly reduced in the NTV group as compared to those in the CC group. Significantly, the magnitude of the reduction in exposure to HPHCs observed in the NTV group (49-94%) was close to that observed for the SA group (39-95%).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 96, July 2018, Pages 127-134
نویسندگان
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