کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551457 | 1562108 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessing the safety of an Ephedrae Herba aqueous extract in rats: A repeat dose toxicity study
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کلمات کلیدی
FDACREAOECDNOAELALTGLPLUCAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییSafety assessment - ارزیابی ایمنیtriglyceride - تریگلیسریدGood Laboratory Practice - تمرین خوب آزمایشگاهیBUN - خوبFood and Drug Administration - سازمان غذا و داروOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهlarge unstained cells - سلول های بی نظیر بزرگRepeated dose toxicity - سمیت دوزهای مجزاPhospholipid - فسفولیپیدF344 rats - موش F344blood urea nitrogen - نیتروژن اوره خونbody weight - وزن بدنcreatinine - کراتینینtotal cholesterol - کلسترول تامGlu - گلوGlucose - گلوکز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ephedrae Herba (EH) has been used in Asian traditional herbal medicine to cure bronchial asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. In this study, we evaluated the subchronic toxicity of an Ephedrae Herba aqueous extract (EHAE) in male and female F344 rats. The EHAE was administered orally daily at doses of 0, 125, 250, 500, and 1000â¯mg/kgâ¯bw/day for 13 weeks. Toxicological assessment was performed to determine mortality, clinical signs, and changes in body weight, food consumption, ophthalmological, urinary, hematological, and serum biochemical parameters, macroscopic and microscopic evaluations, and organ weights. We found that oral administration of EHAE to F344 rats for 13 weeks resulted in histopathological changes in the kidneys and salivary glands. In the kidneys, increased incidence and severity of tubular basophilia were observed in females administered 1000â¯mg/kgâ¯bw/day of the extract. In the salivary glands, acinar cell hypertrophy was observed in males administered 500â¯mg/kgâ¯bw/day and in both sexes administered 1000â¯mg/kgâ¯bw/day of the extract. All test article-treated groups of males and females administered â¥250â¯mg/kgâ¯bw/day showed increased absolute and relative salivary gland weights. Therefore, the NOAEL (No Observed Adverse Effect Level) was determined as 125â¯mg/kgâ¯bw/day for both sexes of rats under the present experimental conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 94, April 2018, Pages 144-151
Journal: Regulatory Toxicology and Pharmacology - Volume 94, April 2018, Pages 144-151
نویسندگان
Hyoung-Yun Han, Jung-Im Huh, So-Ri Han, Myung-Gyun Kang, Seokjoo Yoon, Ji-Seok Han, Byoung-Seok Lee, Jeong Ah Kim, Byung-Sun Min,