کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8552566 | 1403369 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A comparison of the effects of lindane and FeCl3/ADP on spontaneous contractions in isolated rat or human term myometrium
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A comparison of the effects of lindane and FeCl3/ADP on spontaneous contractions in isolated rat or human term myometrium A comparison of the effects of lindane and FeCl3/ADP on spontaneous contractions in isolated rat or human term myometrium](/preview/png/8552566.png)
چکیده انگلیسی
Oxidative stress affects the contractile behavior of smooth muscle resulting in complications during labor. Toxicants such as lindane and ferric chloride (FeCl3)/adenosine diphosphate (ADP) cause oxidative stress and have previously been shown to inhibit smooth muscle contraction. In this study we examined the effects of the oxygen species scavengers, ascorbic acid and N-acetylcysteine on lindane and FeCl3/ADP's inhibition of spontaneous myometrial contractions in rat and human myometrium. Lindane and FeCl3/ADP gave rise to concentration-dependent reductions in rat (EC50 11.8Â ÃÂ 10â6Â M and 0.9Â ÃÂ 10â3Â M) and human myometrial contractions (EC50 16.3Â ÃÂ 10â6Â M and 1.1Â ÃÂ 10â3Â M, respectively). Pre-treatment with N-acetylcysteine significantly increased the EC50 for the effects of lindane on motility index of human tissue and reduced the maximum inhibitory effect of FeCl3/ADP on contractions in both rat and human myometrium. Ascorbic acid reduced the effects of FeCl3/ADP in rat tissue only. In conclusion pre-treatment with specific antioxidants may protect both rat and human myometrium from the inhibitory effects of lindane and FeCl3/ADP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 74, December 2017, Pages 164-173
Journal: Reproductive Toxicology - Volume 74, December 2017, Pages 164-173
نویسندگان
Rebecca A. Fanning, Deirdre P. Campion, Maeve O'Shea, Michael F. Carey, John J. O'Connor,