کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553119 | 1562578 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine
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کلمات کلیدی
DPHPMPHPMEHPNOAELtmaxDEHPAUC - AUCdi-(2-ethylhexyl) phthalate - di- (2-اتیل هگزیل) فتالاتmono-(2-ethylhexyl) phthalate - mono (2-ethylhexyl) phthalateUrine - ادرار Human - انسانBlood - خونOral exposure - قرار گرفتن در معرض دهانMetabolites - متابولیت هاNo observed adverse effect level - هیچ عوارض جانبی مشاهده نشدهbody weight - وزن بدنPVC - پلیوینیل کلراید یا پیویسیPolyvinyl chloride - کلرید پلی وینیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2â¯mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metabolites in blood and urine of 6 male volunteers over time following ingestion of a single DPHP dose (0.7â¯mg/kg body weight). Concentration-time courses in blood were obtained up to 24â¯h for DPHP, mono-(2-propylheptyl) phthalate (MPHP), mono-(2-propyl-6-hydroxyheptyl) phthalate (OH-MPHP), and mono-(2-propyl-6-oxoheptyl) phthalate (oxo-MPHP); amounts excreted in urine were determined up to 46â¯h for MPHP, OH-MPHP, oxo-MPHP, and mono-(2-propyl-6-carboxyhexyl) phthalate (cx-MPHP). All curves were characterized by an invasion and an elimination phase the kinetic parameters of which were determined together with the areas under the concentration-time curves in blood (AUCs). AUCs were: DPHPâ¯>â¯MPHPâ¯>â¯oxo-MPHPâ¯>â¯OH-MPHP. The amounts excreted in urine were: oxo-MPHPâ¯>â¯OH-MPHP>â¯>â¯cx-MPHPâ¯>â¯MPHP. The AUCs of MPHP, oxo-MPHP, or OH-MPHP could be estimated well from the cumulative amounts of urinary OH-MPHP or oxo-MPHP excreted within 22â¯h after DPHP intake. Not considering possible differences in species-sensitivity towards unconjugated DPHP metabolites, it was concluded from a comparison of their AUCs in DPHP-exposed humans with corresponding earlier data in rats that there is no increased risk of adverse effects associated with the internal exposure of unconjugated DPHP metabolites in humans as compared to rats when receiving the same dose of DPHP per kg body weight.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 294, 15 September 2018, Pages 105-115
Journal: Toxicology Letters - Volume 294, 15 September 2018, Pages 105-115
نویسندگان
D. Klein, W. Kessler, C. Pütz, B. Semder, W. Kirchinger, A. Langsch, W. Gries, R. Otter, A.K.E. Gallien, X. Wurzenberger, J.G. Filser,