کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553362 | 1562584 | 2018 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of lead exposure on the expression of HMGB1 and HO-1 in rats and PC12 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Lead (Pb) is an environmental neurotoxic metal. Chronic exposure to Pb causes deficits of learning and memory in children and spatial learning deficits in developing rats. In this study we investigated the effects of Pb exposure on the expression of HMGB1 and HO-1 in rats and PC12 cells. The animals were randomly divided to three groups: control group; low lead exposure group; high lead exposure group; PC12 cells were divided into 3 groups: 0â¯Î¼M (control group), 1â¯Î¼M and 100â¯Î¼M Pb acetate. The results showed that Pb levels in blood and brain of Pb exposed groups were significantly higher than that of the control group (pâ¯<â¯0.05). The expression of HMGB1 and HO-1 were increased in Pb exposed groups than that of the control group (pâ¯<â¯0.05). Moreover, we found that the up-regulation of HO-1 in Pb exposure environment inhibited the expression of HMGB1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 111-118
Journal: Toxicology Letters - Volume 288, 15 May 2018, Pages 111-118
نویسندگان
Meiyuan Yang, Yaobin Li, Ying Wang, Nuo Cheng, Yi Zhang, Shimin Pang, Qiwei Shen, Lijuan Zhao, Guilin Li, Gaochun Zhu,