Influence des interactions entre l'absorption intestinale du sodium et du glucose sur le métabolisme glucidique

Metabolic diseases such as obesity, hypertension and type 2 diabetes have seen their prevalence increased dramatically worldwide. In parallel, eating habits have profoundly changed in recent decades with the increase in the consumption of foods rich in salt and sugars. Clinical studies highlight the previously unsuspected role of salt, the main source of sodium, on the rise in post-prandial glycemic response and the risk of developing type 2 diabetes. Recently, we unveiled the effect of bile diversion in gastric bypass on sodium glucose transport and post-prandial glucose homeostasis, through the modulation of intestinal trafficking of endogenous sodium. This mechanism is consistent with available clinical evidence, and opens up new perspectives in metabolic surgery. More generally, the modulation of intestinal sodium/glucose cotransport appears as a promising avenue to prevent or treat type 2 diabetes.