کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8625195 | 1568112 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: The cardiovascular health study
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کلمات کلیدی
FGF23VDRpTH24,25(OH)2DACRCKD-MBDCHSDBPEGFR1,25(OH)2D - 1،25 (OH) 2D1,25-dihydroxyvitamin D - 1،25-دی هیدروکسوییتامین D25(OH)D - 25 (OH) D25 hydroxyvitamin D - 25 هیدروکسی ویتامین دalbumin/creatinine ratio - آلبومین / کراتینین نسبتosteodystrophy - استئودیستروفیBone density - تراکم استخوان Fracture - شکستگیfibroblast growth factor 23 - فاکتور رشد فیبروبلاست 23Cardiovascular Health Study - مطالعه سلامت قلب و عروقestimated glomerular filtration rate - میزان تصفیه گلومرولی برآورد شده استVitamin D - ویتامین دیVitamin D binding protein - پروتئین متصل به ویتامین DVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
25-hydroxyvitamin D [25(OH)D] may not optimally indicate vitamin D receptor activity. Higher concentrations of its catabolic product 24,25-dihydroxyvitmin D [24,25(OH)2D] and a higher ratio of 24,25(OH)2D to 25(OH)D (the vitamin D metabolite ratio [VMR]) may provide additional information on receptor activity. We compared the strength of associations of these markers with serum PTH concentrations, hip bone mineral density (BMD), and risk of incident hip fracture in community-living older participants in the Cardiovascular Health Study. Among 890 participants, the mean age was 78 years, 60% were women, and the mean 25(OH)D was 28 ± 11 ng/ml. In cross-sectional analysis, the strength of association of each vitamin D measure with PTH was similar; a 1% higher 25(OH)D, 24,25(OH)2D, and VMR were associated with 0.32%, 0.25%, and 0.26% lower PTH, respectively (p < 0.05 for all). Among 358 participants with available BMD data, we found no associations of 25(OH)D or VMR with BMD, whereas higher 24,25(OH)2D was modestly associated with greater hip BMD (1% higher 24,25(OH)2D associated with 0.04% [95% CI 0.01-0.08%] higher BMD). Risk of incident hip fracture risk was evaluated using a case-cohort design. There were 289 hip fractures during a mean follow up time of 8.4 years. Both higher 24,25(OH)2D and VMR were associated with lower risk of hip fracture (HR per SD higher, 0.73 [0.61, 0.87] and 0.74 [0.61, 0.88], respectively) whereas 25(OH)D was not associated with hip fracture (HR 0.93 [0.79, 1.10]). We conclude that evaluating vitamin D status by incorporating assessment of 24,25(OH)D and the VMR provides information on bone health above and beyond 25(OH)D alone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 107, February 2018, Pages 124-130
Journal: Bone - Volume 107, February 2018, Pages 124-130
نویسندگان
Charles Ginsberg, Ronit Katz, Ian H. de Boer, Bryan R. Kestenbaum, Michel Chonchol, Michael G. Shlipak, Mark J. Sarnak, Andrew N. Hoofnagle, Dena E. Rifkin, Pranav S. Garimella, Joachim H. Ix,