کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8645539 | 1569789 | 2018 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle
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کلمات کلیدی
qPCRfork stalling and template switchingFoSTesNAHRCNVsNHEJCDMSNPsAssociation - اتحادیهExpression - اصطلاحnon-homologous end-joining - عدم پیوستن به همولوگGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومNon-allelic homologous recombination - نوترکیب همولوگ مشابه غیر آللquantitative real-time PCR - واکنش زنجیره ای پلیمراز واقعی در زمان واقعیSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیCopy number variations - کپی تغییرات شمارهCattle - گاو
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle Associations of GBP2 gene copy number variations with growth traits and transcriptional expression in Chinese cattle](/preview/png/8645539.png)
چکیده انگلیسی
Copy number variations (CNVs) recently have been recognized as another important genetic variability followed single nucleotide polymorphisms (SNPs). The guanylate binding protein 2 (GBP2) gene plays an important role in cell proliferation. This study was performed to determine the presence of GBP2 CNV (relative to Angus cattle) in 466 individuals representing six main cattle breeds from China, identify its relationship with growth, and explore the biological effects of gene expression. There were two CNV regions in the GBP2 gene, for three types, CNV1 loss type (relative to Angus cattle) was more frequent in XN than other breeds, and CNV2 loss type (relative to Angus cattle) was more frequent in XN and CDM than other breeds. Though the GBP2 gene copy number presented no correlation with the transcriptional expression of JX (Pâ¯>â¯.05), but the transcriptional expression in heart is higher than other tissues, and the copy number in muscles and fat of JX is higher than others breeds. Statistical analysis revealed that the GBP2 gene CNV1 and CNV2 were significantly associated with growth traits (Pâ¯<â¯.05). In conclusion, this research established the correlations between CNVs of GBP2 gene and growth traits in different cattle breeds, and our results suggested that the CNVs in GBP2 gene may be considered markers for the molecular breeding of Chinese beef cattle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 647, 20 March 2018, Pages 101-106
Journal: Gene - Volume 647, 20 March 2018, Pages 101-106
نویسندگان
Gui-Min Zhang, Li Zheng, Hua He, Cheng-Chuang Song, Zi-Jing Zhang, Xiu-Kai Cao, Chu-Zhao Lei, Xian-Yong Lan, Xing-Lei Qi, Hong Chen, Yong-Zhen Huang,