کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646045 | 1569794 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression profiles of the p38 MAPK signaling pathway from Chinese shrimp Fenneropenaeus chinensis in response to viral and bacterial infections
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کلمات کلیدی
p38mitogen-activated protein kinase kinase 3MKK6V. anguillarumFenneropenaeus chinensisMKK3ATF-2mitogen-activated protein kinase kinase 4MKK4Vibrio anguillarumWSSVRT-PCRERKs - ERK هاMAPK - MAPKRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهStaphylococcus aureus - استافیلوکوک اورئوسS. aureus - استافیلوکوکوس اورئوسBacteria - باکتریANOVA - تحلیل واریانس Analysis of varianceone-way analysis of variance - تحلیل واریانس یک راههRNA interference (RNAi) - تداخل RNA (RNAi)reverse transcription PCR - رونویسی معکوس PCRactivating transcription factor 2 - فعال کردن عامل رونویسی 2White spot syndrome virus - ویروس سندرم سفید سفیدmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenExpression profiles - پروفایل های بیانextracellular signal-regulated kinases - کیناز های تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mitogen-activated protein kinase (MAPK) signaling pathway plays an important role in cellular response to inflammatory cytokines, environmental stress and pathogenic infection, However, compared with mammals and insects, the potential function of p38 MAPK from Chinese shrimp (Fenneropenaeus chinensis) in response to viruses and bacterial infection is limited. In the study, the immune responses of four genes MKK3, MKK4, p38 and ATF-2 from F. chinensis were investigated in defending against white spot syndrome virus (WSSV), Vibrio anguillarum (V. anguillarum) and Staphylococcus aureus (S. aureus) infection. Results demonstrated that the expression levels of these four genes were apparently modulated in hemocytes and gills when shrimp were stimulated by WSSV or bacteria, particularly at 3-24Â h after infection. MKK3, p38 and ATF-2 were most sensitive to V. anguillarum (Gram-negative bacteria), followed by WSSV and S. aureus (Gram-positive bacteria), while MKK4 gene was most sensitive to S. aureus, followed by WSSV and V. anguillarum. Knockdown of Fcp38 by RNA interference (RNAi) resulted in a reduction in the expression of FcMKK3 and FcATF-2. The results indicate that p38MAPK signaling pathway plays a role in defending against viral and bacterial infections in F. chinensis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 642, 5 February 2018, Pages 381-388
Journal: Gene - Volume 642, 5 February 2018, Pages 381-388
نویسندگان
Yuying He, Wanlong Yao, Ping Liu, Jian Li, Qingyin Wang,