کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8648450 | 1570692 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke
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کلمات کلیدی
MRSCXC chemokine receptor 2TNFPE-Cy7PerCPCXCL8CXCR2PBMCsDWIAPCMIRRT-PCRGEOROCFACSPBSDMEMFITCFBSnatural killer - (سلول های) کشنده طبیعیAUC - AUCDulbecco’s modified Eagle medium - Modified Eagle اصلاح شده Dulbeccoallophycocyanin - آلوفوکسیانینstandard deviation - انحراف معیارinterferon - اینترفرونIFN - اینترفرون هاInterleukin-8 - اینترلوکین -8ELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاdiffusion-weighted imaging - تصویربرداری با وضوح تصویربرداریcluster of differentiation - خوشه تمایزfluorescence-activated cell sorting - دسته بندی سلول های فعال فلورسنسfetal bovine serum - سرم جنین گاوperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیNatural killer cells - سلولهای کشنده طبیعیIschemic stroke - سکته مغزی ایسکمیکtumor necrosis factor - فاکتور نکروز تومورPhosphate buffered saline - فسفات بافر شورfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتModified Rankin scale - مقیاس رنکین اصلاح شدهarea under the curve - منطقه تحت منحنیMicroRNA - میکرو RNA wildtype - نوع وحشیprognosis - پیش شناخت بیماریGene Expression Omnibus - ژن بیان Omnibusnegative control - کنترل منفیGranulocytes - گرانولسیت هاreceiver operating characteristic - گیرنده عامل عامل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic stroke](/preview/png/8648450.png)
چکیده انگلیسی
Granulocytes and natural killer (NK) cells have been linked to brain injury in ischemic stroke. However, their recruitment from peripheral leucocytes in stroke patients is not well understood. Here, the expression of the interleukin 8 (CXCL8) in plasma, and CXC chemokine receptor 2 (CXCR2) in peripheral leucocytes of patients with ischemic stroke were evaluated. Based on the results, CXCR2 expression positively correlated with granulocytes and NK cells, which were in turn attracted by CXCL8. The results also indicated that CXCR2 was a direct target of microRNA (miR)-4437, a negative regulator of CXCR2, which was downregulated in peripheral leucocytes from patients with ischemic stroke. Furthermore, serum CXCL8 levels were associated with the infarct volume and functional outcomes in patients with ischemic stroke. The results of the receiver operating characteristic curve analysis with an optimal cut-off value of 34âpg/mL indicated serum CXCL8 levels could be a prognostic indicator for ischemic stroke. In conclusion, these data highlighted the involvement of the CXCL8-CXCR2 chemotactic axis in the recruitment of granulocytes and NK cells in ischemic stroke. Furthermore, miR-4437 was suggested as a novel target for treating ischemic stroke, while the serum CXCL8 level could be a prognostic factor for ischemic stroke.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 101, September 2018, Pages 440-449
Journal: Molecular Immunology - Volume 101, September 2018, Pages 440-449
نویسندگان
Qianyi He, Xiaojuan Shi, Bin Zhou, Junfang Teng, Chaoqi Zhang, Shasha Liu, Jingyao Lian, Benyan Luo, Guoqiang Zhao, Hong Lu, Yuming Xu, Yajun Lian, Yanjie Jia, Yi Zhang,